Understanding Immunosuppression after Sepsis

Lactate and Immunosuppression in Sepsis

Serum lactate levels are traditionally interpreted as a marker of tissue hypoxia and often used clinically as an indicator of severity and outcome of sepsis/septic shock. Interestingly, recent studies involving the effects of tumor-derived lactate suggest that lactate itself may have an immunosuppressive effect in its local environment. This finding adds to the recent advances in immunometaboli...

Potential Immunotherapeutics for Immunosuppression in Sepsis

Sepsis is a syndrome characterized by systemic inflammatory responses to a severe infection. Acute hyper-inflammatory reactions in the acute phase of sepsis have been considered as a primary reason for organ dysfunction and mortality, and advances in emergency intervention and improved intensive care management have reduced mortalities in the early phase. However it has been recognized that inc...

Immunosuppression after Liver Transplantation

Assessment of sepsis-induced immunosuppression at ICU discharge and 6 months after ICU discharge

BACKGROUND Increase in mortality and in recurrent infections in the year following ICU discharge continues in survivors of septic shock, even after total clinical recovery from the initial septic event and its complications. This supports the hypothesis that sepsis could induce persistent long-term immune dysfunctions. To date, there is almost no data on ICU discharge and long-term evolution of...

Sepsis Immunosuppression after Polymicrobial in the Bone Marrow Mediates Sustained Modulation of Dendritic Cell Differentiation